Tartrazine is a synthetic lemon yellow azo dye primarily used as a food coloring.
Azo dyes are widely used in the food, pharmaceutical, cosmetic, textile, and leather industries. They are synthetic compounds characterized by one (monoazo) or several intramolecular NQN bonds.Azo dyes, if they are systemically absorbed, can be metabolized via azoreductases of intestinal microflora by liver cells and skin surface bacteria.
This metabolism leads to aromatic amines that can be hazardous.
Aromatic amines are chemicals found in industrial and manufacturing plants, tobacco smoke, commercial hair dyes, and diesel exhaust. Many are carcinogens and endocrine disruptors that may increase the risk of breast cancer.
It also has a group of chemical compounds, some of which are known to be capable of causing cancer. They include benzidine, B-naphthylamine and 4-amino diphenyl.
Tartrazine: “tartrazine acts either directly or indirectly upon the muscarinic acetylcholine receptor associated with parasympathetic innervation,” causing a chain reaction of effects to the nervous system.
However, according to www.epa.gov/saferchoice/safer-ingredients, The chemical Tartrazine, has been verified to be of low concern.
It is considered “to be of low concern” and used in thousands of products, in spite of all of the previous listed side affects and reactions in the bodies, of those consuming it.
Just a few references for information listed above.
https://pubchem.ncbi.nlm.nih.gov/compound/Tartrazine#section=Mechanism-of-Action
https://en.wikipedia.org/wiki/Tartrazine
https://www.sciencedirect.com/topics/chemistry/aromatic-amine
https://www.bcpp.org/resource/aromatic-amines
https://medical-dictionary.thefreedictionary.com/aromatic+amines
https://www.sciencedirect.com/topics/neuroscience/
https://pubchem.ncbi.nlm.nih.gov/compound/acetylcholine
https://pubmed.ncbi.nlm.nih.gov/7768353
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